WHY PROTO360

Anyone can sell a program.
We built a standard.

Physician developed, not marketer assembled. Five health domains treated as one system. Outcomes you can measure and defend. That is the difference between a weight loss offering and clinical infrastructure.

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/ MEDICAL LEADERSHIP /

Built by Metabolic
Medicine Specialists

Proto360 was designed by physicians who have spent over a decade treating metabolic disease at one of the nation’s largest weight management organizations. Our founders are dual board-certified in Obesity Medicine and Emergency Medicine, bringing both clinical depth and operational intensity to every aspect of the protocol.

This isn’t a wellness trend adapted for clinical use. It’s a medical system built from more than 50,000 real patient encounters, refined through evidence-based practice, and engineered to scale.

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Our Physicians

Designed by the physicians
who ran the clinics.

Proto360 was not adapted from a consumer wellness product. Both founders are dual board-certified in Emergency Medicine and Obesity Medicine, both ran clinical operations at national scale, and both were at the same weight management platform before building this one. In 2024 they co-authored a white paper on the metabolic effects of GLP-1 therapy and weight loss.

Katrina Mattingly, MD, DABOM
Co-Founder and Chief Medical Officer

Dual board-certified in Emergency Medicine and Obesity Medicine. For eleven years she was founding Chief Medical Officer and partner at a national weight management platform, scaling it from a single clinic to 42 locations across nine states and more than 15,000 patients a month.

She built the clinical operating system behind that growth, and co-developed the biological age and metabolic scoring system Proto360 now uses to show whether a patient is actually getting healthier. She trained in emergency medicine at the University of Chicago Medical Center and still practices today.

Board Certified
Emergency Medicine (ABEM). Obesity Medicine (ABOM).
Training
Emergency Medicine Residency, University of Chicago Medical Center
Operated At
42 locations across nine states, 15,000+ patients monthly
Licensure
Active in thirteen states
John Mulligan, MD
Co-Founder

Dual board-certified in Emergency Medicine and Obesity Medicine, with an MBA from Northwestern's Kellogg School of Management. As Chief Clinical Officer at that same platform he built the treatment protocols and provider training behind a $45M clinical portfolio and the medical infrastructure for more than twenty new clinics.

Before that he ran clinical operations at national scale: 5,000 clinicians across 450 contracts in 38 states at US Acute Care Solutions, and 1,500 clinicians and three million annual patient visits at Alteon Health. He trained in emergency medicine at Johns Hopkins Hospital and served as a Major in the US Army Medical Corps.

Board Certified
Emergency Medicine (ABEM). Obesity Medicine (ABOM). FACEP.
Training
Emergency Medicine Residency, Johns Hopkins Hospital. MBA, Kellogg School of Management, Northwestern University.
Operated At
5,000+ clinicians across 450 contracts in 38 states
Licensure
Active in twenty-three states

A Real Medical
Difference

01

Physician Developed

Every aspect of Proto360 was designed by board-certified physicians with deep expertise in metabolic medicine with an awareness of but not adapted from consumer wellness trends.

02

Five-Domain Integration

Our protocol integrates pharmacotherapy, nutrition, behavior change, biomarker monitoring, and clinical decision support into one unified system.

03

Measurable Infrastructure

Built-in measurement at every stage. Track outcomes, demonstrate ROI, and make evidence-based adjustments throughout the patient journey.

PRECISION PARTNER

Most programs guess. We test first.

The usual approach is to prescribe whatever is in demand and see what happens. Through our partnership with Phenomix Sciences, Proto360 patients are phenotyped at baseline with the MyPhenome test, so the medication is matched to biology we measured. Phenomix has published what that difference looks like across the major drug classes.

Phentermine-Topiramate
11% total body weight loss under standard prescribing. Roughly 20% when the phenotype is matched first.
Bupropion-Naltrexone
6% total body weight loss under standard prescribing. 12% when the phenotype is matched first.
GLP-1
8% to 21% total body weight loss under standard prescribing. Roughly 20% when the phenotype is matched first.
Figures published by Phenomix Sciences. Standard efficacy from Voelker R, JAMA 2025;333(1):96. Phenotype-guided figures from Phenomix internal validation (November 2023), Acosta et al., Obesity 29:4 (2021), and Mayo Clinic research presented by Sima Fansa, MD, at DDW, May 2024. Individual results vary.
Build, Rent, or Run It Properly

Three paths.
The differences show up in year one.

Most practices considering metabolic care land on one of three options. It is worth being honest about what each one costs you beyond the invoice.

 
Build in-house
Generic weight-loss vendor
Proto360
Time to first patient
Build in-house9–18 months
Generic vendor2–4 weeks
Proto360Under 30 days
Clinical protocol
Build in-houseYou write and maintain it
Generic vendorGeneric, rarely clinician-authored
Proto360Physician-developed, criteria-gated
Lean mass protection
Build in-houseOnly if you design for it
Generic vendorSeldom addressed
Proto360Built into every phase
Remote monitoring
Build in-houseSeparate vendor to integrate
Generic vendorUsually none
Proto360Integrated into the protocol
Outcome data
Build in-houseYou build the reporting
Generic vendorVendor-held, if captured at all
Proto360Practice-level analytics you keep
Patient relationship
Build in-houseYours
Generic vendorOften the vendor's brand
Proto360Yours, under your brand
Ongoing maintenance
Build in-houseYour team, indefinitely
Generic vendorWhatever is on their roadmap
Proto360Protocol updates included
Straight Answers

The questions practices
actually ask.

Not the comfortable ones. These are the objections that come up in the second call, once the pitch is over.

Does this increase my liability?+

You remain the treating provider and retain clinical judgment throughout. Proto360 supplies protocol structure, monitoring, and documentation. It does not diagnose or prescribe. In practice, a documented, criteria-gated pathway tends to strengthen the clinical record rather than weaken it. Your malpractice carrier should review the arrangement, and we will supply whatever they ask for.

Will this cannibalize my existing visits?+

Generally it runs alongside existing care rather than replacing it. The patients who enter the protocol are usually ones you were managing episodically, or not managing at all because there was no structure to offer them.

Who owns the patient relationship?+

You do. The patient experience is white-labeled to your practice: your brand on the app, the portal, and every communication. Patients are your patients, and they stay that way.

What happens to my patients if I leave the platform?+

Patient data is exportable and termination includes a defined transition path, so care is not stranded mid-phase. The specifics live in the provider agreement, and we would encourage you to read that section closely before signing rather than after.

Do I have to change EHRs?+

No. The platform is built to integrate with what you already run rather than replace it. Integration scope varies by system, and we will tell you plainly during onboarding what does and does not sync.

How much of my staff's time does this take?+

Onboarding is the heaviest lift: credentialing, setup, and training inside the first 30 days. At steady state most routine touchpoints shift to coaching and remote monitoring, which is the point.

Is an AI making clinical decisions?+

No. The protocol logic is deterministic and guardrailed, and the provider is in the loop for every clinical decision. Where intelligent assistance is used, it supports follow-up and milestone tracking. It does not decide treatment.

Capacity, outcomes, and revenue without added risk.

Partner with Proto360 to bring clinical-grade metabolic care to your patients, employees, practice or enterprise, backed by a complete infrastructure that handles the complexity for you.

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